Key result
Primary cutaneous angiosarcoma presented mostly as cutaneous nodules (47.2%), which, along with scalp location and multiple skin lesions, were associated with significantly reduced overall survival.
Why the study?
Primary cutaneous angiosarcoma is a rare but aggressive tumor with high local recurrence, prompting an analysis of clinicopathological features and cutaneous manifestations associated with prognosis.
Cohort (n=55)
In primary cutaneous angiosarcoma, scalp location, nodular morphology, and multiple skin lesions are associated with worse overall survival.
Scalp location, nodular morphology, and multifocal lesions predict worse survival; hypothesis-generating for risk-stratified surveillance in primary cutaneous angiosarcoma.
BACKGROUND: Primary cutaneous angiosarcoma (CA) is a rare but aggressive tumor with a high rate of local recurrence. This study was designed to analyze the clinicopathological features of primary CA and identify factors of cutaneous manifestations associated with the prognosis of angiosarcoma. METHODS: Medical records of 55 patients with primary CA were retrospectively analyzed to investigate clinical features, survivals, and prognostic factors. Anatomical location of tumor was classified to the scalp, face, and neck, and sites outside the head and neck. RESULTS: Primary CA presented cutaneous nodules (31/55, 47.2%), patches (13/55, 23.6%), and indurated plaques (11/55, 20.0%). Nodular lesion was significantly more common in CA on the scalp compared to CA on sites outside the scalp. Histologically, tumors presenting as nodular lesions on the scalp was predominantly composed of solid sheets of large pleomorphic cells, whereas non-nodular lesions composed of tumor cells between collagen bundles forming irregular vascular spaces. Cutaneous angiosarcoma on the scalp showed a worse prognosis compared to CA on sites outside the scalp. Patients presenting clinical morphology with nodules and multiple skin lesions showed significantly reduced overall survival (OS). CONCLUSION: In primary CA, location on the scalp, morphology with nodules, and multiplicity of skin lesions significantly affected survival outcomes.
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Moon et al. (2020) conducted a cohort in Primary cutaneous angiosarcoma (n=55). Scalp location, nodular morphology, and multiple skin lesions vs. Non-scalp location, non-nodular morphology, and single lesions was evaluated on Overall survival. Primary cutaneous angiosarcoma presented mostly as cutaneous nodules (47.2%), which, along with scalp location and multiple skin lesions, were associated with significantly reduced overall survival.
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