Food protein-derived antihypertensive peptides regulate the renin-angiotensin system primarily through ACE inhibition, renin inhibition, AT1R blockade, and ACE2 activation.
Food-derived antihypertensive peptides offer a potential alternative for hypertension management by modulating multiple key factors of the renin-angiotensin system.
Food protein-derived antihypertensive peptides have attracted substantial attention as a safer alternative for drugs. The regulation of the renin-angiotensin system (RAS) is an essential aspect underlying the mechanisms of antihypertensive peptides. Most of the identified antihypertensive peptides exhibit the angiotensin-converting enzyme (ACE) inhibitory effect. In addition, artificial intelligence has improved the efficiency of ACE inhibitory peptide identifications. Moreover, the inhibition of renin and blockade or down-regulation of angiotensin type I receptor (AT1R) have also been demonstrated to be effective intervention strategies. With the identification of the ACE2/Ang (1-7)/MasR axis, activation or up-regulation of angiotensin-converting enzyme 2 (ACE2) has also emerged as a new intervention pathway. This review summarizes the research progress of antihypertensive peptides in intervening with hypertension from the perspective of their properties, sources, and key factors. The objective of this review is to provide theoretical references for the development of antihypertensive peptides and the explorations of the molecular mechanisms.
Yao et al. (2024) conducted a review in Hypertension. Food protein-derived antihypertensive peptides was evaluated. Food protein-derived antihypertensive peptides regulate the renin-angiotensin system primarily through ACE inhibition, renin inhibition, AT1R blockade, and ACE2 activation.