The DPE, a Conserved Downstream Core Promoter Element That Is Functionally Analogous to the TATA Box

Transcription by RNA polymerase II is a fundamentaland important biological process. There are tens of thousands of diverse genes that are transcribed in a highly regulated manner by the RNA polymerase II transcriptionalmachinery, and thus the mechanisms by which transcription is controlled are necessarily complex (for reviews,see Conaway and Conaway 1993; Smale 1994; Koleskeand Young 1995; Zawel and Reinberg 1995; Björklundand Kim 1996; Kaiser and Meisterernst 1996; Orphanides et al. 1996; Reines et al. 1996; Roeder 1996;Svejstrup et al. 1996; Verrijzer and Tjian 1996)...