It is demonstrated by means of the leucocyte migration technique that a hypersensitivity of the delayed type seems to be involved in the hypertensive disease in patients suffering from primary essential hypertension. In culture chambers containing 50 micrograms/ml of femoral arterial protein, the six of the seven examined hypertensive patients showed a migration index equal to or below 0.8, the lowest being 0.64. The normotensive control persons showed migration indices varying from 0.9 to 1.06. These indices were clearly distinguished from the indices of the hypertensive patients. The antigenic substance(s) in the arteries are still unknown.
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Olsen et al. (1973) studied this question.
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