November 9, 1999Circulation
Intravenous Arginine-Vasopressin in Children With Vasodilatory Shock After Cardiac Surgery
Key result
Intravenous arginine-vasopressin significantly increased systolic blood pressure from 65 to 87 mm Hg during the first hour of treatment in children with refractory vasodilatory shock (P<0.0001).
Why the study?
Does intravenous arginine-vasopressin improve systolic blood pressure in children with vasodilatory shock after cardiac surgery?
Population
11 profoundly ill infants and children ages 3 days to 15 years with hypotension after cardiac surgery…
Design
Case_series
Follow-up
intensive care unit stay
Authors
Discussion
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Member takes
Implication
May support adjunctive use in select refractory cases; leaves open need for randomized confirmation before practice change.
Study Design
Type
Observational (n=11)
Multicenter
No
Structured PICO
Does intravenous arginine-vasopressin improve systolic blood pressure in children with vasodilatory shock after cardiac surgery?
P
Population
11 profoundly ill infants and children (median age 35 days) with refractory hypotension after cardiac surgery treated with arginine-vasopressin.
E
Exposure
Intravenous arginine-vasopressin (AVP) at doses ranging from 0.0003 to 0.002 U.kg(-1).min(-1)
O
Outcome
Change in systolic blood pressure during the first hour of treatmentsurrogate
Main Result
Absolute Event Rate: 87% vs 65%
p-value: p=<0.0001
Intravenous arginine-vasopressin effectively increases systolic blood pressure in infants and children with vasodilatory shock after cardiac surgery who have adequate cardiac function.
Cite This Study
Rosenzweig et al. (1999) conducted an observational in Vasodilatory shock / refractory hypotension after cardiac surgery (n=11). Intravenous Arginine-Vasopressin (AVP) vs. Baseline (pre-treatment) was evaluated on Systolic blood pressure during the first hour of treatment (p=<0.0001). Intravenous arginine-vasopressin significantly increased systolic blood pressure from 65 to 87 mm Hg during the first hour of treatment in children with refractory vasodilatory shock (P<0.0001).