Why the study?
Do high-positive anticardiolipin antibodies increase the risk of antiphospholipid antibody-related disorders compared to low-positive or negative titers in women undergoing clinically indicated testing?
Population
474 women who underwent clinically indicated testing for antiphospholipid antibodies
Comparison
High-positive antiphospholipid antibodies vs Low-positive IgG, IgM only, or negative
Design
Cohort
Follow-up
median at least 4 years
Authors
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Low-positive anticardiolipin titers were not linked to excess complications; leaves open whether refined thresholds should guide APS risk stratification.
Do high-positive anticardiolipin antibodies increase the risk of antiphospholipid antibody-related disorders compared to low-positive or negative titers in women undergoing clinically indicated testing?
Women with low levels of IgG or IgM anticardiolipin antibodies do not have an increased risk of antiphospholipid antibody-related disorders compared to those with negative tests, unlike those with high-positive titers.
Silver et al. (1996) studied this question.
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