Key result
Mitochondrial dysfunction plays a vital role in the development of spinal cord injury, and drugs enhancing mitochondrial function serve as potential therapeutic candidates.
Why the study?
To review advances in the role of mitochondrial dysfunction in spinal cord injury and its relevant treatments.
Mitochondrial dysfunction serves as a potential therapeutic target for spinal cord injury, providing a basis for future therapeutic candidates.
Mitochondrial-targeted strategies merit preclinical refinement in SCI; leaves open translation to clinical trials.
Objective: To review the advances of the role of mitochondrial dysfunction in the spinal cord injury (SCI) and its relevant treatments. Methods: Focusing on various mechanisms of mitochondrial dysfunction, recent relevant literature at home and abroad was identified to summarize the therapeutic strategies for SCI. Results: Mitochondrial dysfunction is mainly manifested in abnormalities in mitochondrial energy metabolism, mitochondrial oxidative stress, mitochondrial-mediated apoptosis, mitophagy, mitochondrial permeability transition, and mitochondrial biogenesis, playing a vital role in the development of SCI. Drug that enhanced mitochondrial function have been proved beneficial for the treatment of SCI. Conclusion: Mitochondrial dysfunction can serve as a potential therapeutic target for SCI, providing ideas and basis for the development of SCI therapeutic candidates in the future.
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Miao et al. (2022) conducted a review in Spinal cord injury. Mitochondrial-targeted therapies was evaluated. Mitochondrial dysfunction plays a vital role in the development of spinal cord injury, and drugs enhancing mitochondrial function serve as potential therapeutic candidates.
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