Electrochemical Nickel Catalysis for Sp 2 -Sp 3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides

A constant-current electrochemical method for reducing catalytic nickel complexes in sp 2 -sp 3 cross-electrophile coupling reactions has been developed. The electrochemical reduction provides reliable nickel catalyst activation and turnover and offers a tunable parameter for reaction optimization, in contrast to more standard activated metal powder reductants. The electrochemical reactions give yields (i.e., 51–86%) and selectivities as high or superior to those using metal powder reductants and provide access to a wider substrate scope.