Why the study?
Does lidocaine inhibit blood coagulation in ex vivo whole blood specimens?
Population
Ex vivo whole blood specimens (n = 20)
Comparison
Serial dilutions of lidocaine hydrochloride to… vs Saline (0.0 mM lidocaine)
Design
Preclinical
Authors
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May impair epidural blood patch efficacy via residual lidocaine; leaves open in vivo clinical relevance.
Does lidocaine inhibit blood coagulation in ex vivo whole blood specimens?
Lidocaine at achievable epidural concentrations impairs blood coagulation ex vivo, suggesting residual lidocaine may contribute to the failure of epidural autologous blood patches.
Tobias et al. (1996) studied this question.
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