Population
Six malignant hyperthermia susceptible (MHS) families, including one three-generation family with 11 meioses.
Design
Preclinical
Authors
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Does not support clinical genetic testing for MHS; leaves open CACNL2A as a candidate locus pending replication in additional families.
The gene encoding the alpha2/delta-subunits of the L-type voltage-dependent calcium channel (CACNL2A) localizes to chromosome 7q and may be linked to some forms of malignant hyperthermia susceptibility.
Iles et al. (1994) studied this question.
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