Key result
Diabetic neuropathy was significantly associated with impaired subclinical left ventricular systolic function, as evidenced by a lower global longitudinal strain (18% vs. 20%, p<0.001) compared to patients without neuropathy.
Why the study?
Is diabetic neuropathy and peripheral nerve conduction associated with subclinical left ventricular systolic dysfunction in patients with diabetes mellitus and preserved LVEF?
Cross-Sectional (n=112)
Single-blind
No
Is diabetic neuropathy and peripheral nerve conduction associated with subclinical left ventricular systolic dysfunction in patients with diabetes mellitus and preserved LVEF?
Absolute Event Rate: 18% vs 20%
p-value: p=<0.001
In patients with diabetes and preserved LVEF, diabetic neuropathy and prolonged F-wave latency are independently associated with subclinical left ventricular systolic dysfunction as measured by global longitudinal strain.
Should not yet change practice; hypothesis-generating for neuropathy as marker of subclinical LV dysfunction in diabetes.
BACKGROUND: Subclinical left ventricular (LV) longitudinal myocardial systolic dysfunction occurs in patients with diabetes mellitus (DM) and preserved LV ejection fraction (LVEF), and is closely related to DM-related complications. However, the association of diabetic neuropathy (DN) with subclinical LV systolic longitudinal dysfunction in such patients has not been fully clarified. METHODS: The subjects of this study were 112 consecutive DM patients with preserved LVEF (all ≥50%) without coronary artery disease and overt heart failure (aged 59 ± 14 years; 60 women, 52 men). Global longitudinal strain (GLS) was determined as the average peak strain of 18 segments from the three standard apical views, and was expressed as an absolute value. DN was diagnosed by experienced diabetologists. Median, ulnar, and sural nerves were subjected to motor and sensory nerve conduction studies. F-wave latency was defined as the minimum F-wave latency after a total of 16 stimulations of the tibial nerve. RESULTS: Forty-one (37%) patients were clinically diagnosed with DN. LV functions of DM patients with and without DN were similar except for GLS being significantly smaller in patients with than in patients without DN (18 ± 2% vs. 20 ± 2%, p < 0.001). It was noteworthy that, of the parameters for the nerve conduction study, only F-wave latency correlated with GLS (r = -0.34, p < 0.001), and also was identified as an independent determinative value of GLS in a multivariate linear regression model (β = -0.25, p = 0.001) even after adjustment for other closely related GLS factors. CONCLUSIONS: Monitoring of F-wave latency may aid early detection of not only DN but also subclinical LV dysfunction. Joint planning of assessment by diabetologists and cardiologists is therefore advisable for better management of DM patients.
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Mochizuki et al. (2015) conducted a cross-sectional in Diabetes mellitus with preserved left ventricular ejection fraction (n=112). Diabetic neuropathy vs. No diabetic neuropathy was evaluated on Global longitudinal strain (GLS) (p=<0.001). Diabetic neuropathy was significantly associated with impaired subclinical left ventricular systolic function, as evidenced by a lower global longitudinal strain (18% vs. 20%, p<0.001) compared to patients without neuropathy.
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