What question did this study set out to answer?

To characterize the 24-hour diurnal secretory patterns of corticosteroids and gonadotropins and determine production rates of estrogens and adrenal steroids in feminizing adrenal cortical carcinoma.

January 1, 1977The Journal of Clinical Endocrinology & Metabolism

Studies of the Diurnal Pattern of Plasma Corticosteroids and Gonadotropins in Two Cases of Feminizing Adrenal Carcinoma: Measurements of Estrogen and Corticosteroid Production

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To characterize the 24-hour diurnal secretory patterns of corticosteroids and gonadotropins and determine production rates of estrogens and adrenal steroids in feminizing adrenal cortical carcinoma.
Evaluated 24-hour plasma corticosteroid and gonadotropin profiles alongside 24-hour mean concentrations of estradiol, estetrol, 11-desoxycortisol, DHEA-S, DHEA, and testosterone in two adult men (N=2).
Measured total production rates of cortisol, 11-desoxycortisol, and estrogens, along with urinary steroid excretion.
Circadian and episodic 24-hour corticosteroid rhythms remained preserved at elevated baselines, with markedly increased cortisol production rates despite only moderate increases in mean 24-hour plasma cortisol.
Plasma estradiol concentrations, urinary excretion, and total estrogen production rates were markedly elevated in both individuals.
Both patients demonstrated measurable plasma estetrol and reduced estriol specific activity relative to estrone and estradiol, with one patient also displaying immunoassayable urinary human chorionic gonadotropin.

Authors

RBROBERT M. BOYARDiakonhjemmet Hospital CNChristopher NogeireAlbert Einstein College of Medicine DFDavid K. FukushimaCreighton University

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Implication

Case series reveals preserved circadian corticosteroid rhythms and high estetrol production in feminizing adrenal carcinoma, suggesting functional similarity to trophoblastic tissue.

Cite This Study

BOYAR et al. (1977) studied this question.

synapsesocial.com/papers/6a95029fc05e7b5813b2ce8b https://doi.org/10.1210/jcem-44-1-39

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Implication

Case series reveals preserved circadian corticosteroid rhythms and high estetrol production in feminizing adrenal carcinoma, suggesting functional similarity to trophoblastic tissue.

Studies of the Diurnal Pattern of Plasma Corticosteroids and Gonadotropins in Two Cases of Feminizing Adrenal Carcinoma: Measurements of Estrogen and Corticosteroid Production

Key Points

Discussion

Implication

Cite This Study

Studies of the Diurnal Pattern of Plasma Corticosteroids and Gonadotropins in Two Cases of Feminizing Adrenal Carcinoma: Measurements of Estrogen and Corticosteroid Production

Key Points

Discussion

Implication

Cite This Study

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