Generating 3D-cultured organoids for pre-clinical modeling and treatment of degenerative joint disease

This is the authors' abstract. We don't add key points for this paper.

Human cell-based and personalized in vitro cartilage models are urgently needed for osteoarthritis treatment in pre-clinical regenerative medicine development. Cellular self-assemblies and condensations of the appropriate stem cells could initiate the formation of transient tissue structures programmed for specific organogenesis processes. 1 This recapitulation of developmental events has previously been demonstrated for the formation of cardiac, epithelial and liver organoids. However, there has been very limited progress in the development of human cartilage organoids for osteoarthritis (OA). 2 Here, we describe the fabrication of functional bioengineered cartilage organoid suitable for OA treatment.