Key result
Severe ulcerative colitis was associated with significantly worse endothelial-dependent dilatation compared to mild disease (8.7% vs 17.3%, P<0.05).
Why the study?
Is increased activity of ulcerative colitis associated with generalized endothelial dysfunction?
Population
66 subjects, including 42 patients with ulcerative colitis and 24 healthy subjects.
Design
Cross-sectional
Authors
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May underlie activity-related complications in UC; hypothesis-generating and needs prospective validation.
Cross-Sectional (n=66)
Is increased activity of ulcerative colitis associated with generalized endothelial dysfunction?
Absolute Event Rate: 8.7% vs 17.3%
p-value: p=<0.05
Increased activity of ulcerative colitis is associated with significant endothelial dysfunction, which may contribute to the pathophysiology of activity-related extraintestinal complications.
Kocaman et al. (2006) conducted a cross-sectional in Ulcerative colitis (n=66). Severe ulcerative colitis vs. Mild ulcerative colitis was evaluated on Endothelial-dependent dilatation (EDD) (p=<0.05). Severe ulcerative colitis was associated with significantly worse endothelial-dependent dilatation compared to mild disease (8.7% vs 17.3%, P<0.05).