Key result
Intraoperative high-volume local infiltration analgesia significantly reduced mean 24-hour opioid consumption (1.15 mg vs 2.52 mg, p=0.02) compared to placebo in patients undergoing direct anterior total hip arthroplasty.
Why the study?
Does local infiltration analgesia reduce opioids consumption and pain in patients undergoing anterior total hip arthroplasty under general anaesthesia?
RCT (n=106)
Double-blind
Randomized
No
Does local infiltration analgesia reduce opioids consumption and pain in patients undergoing anterior total hip arthroplasty under general anaesthesia?
Absolute Event Rate: 1.15% vs 2.52%
p-value: p=0.02
Local infiltration analgesia reduces opioid consumption and pain following anterior total hip arthroplasty.
Supports routine use of local infiltration analgesia in anterior THA to limit opioid exposure; confirms efficacy in this RCT.
Local infiltration analgesie (LIA) in total hip arthroplasty (THA) is widely used to reduce severe postoperative pain which may delay recovery and rehabilitation [1,2]. The goal is to achieve adequate pain relief in combination with optimal muscle function, allowing early mobilization [3-7]. Multimodal analgesia in combination with LIA is meant to reduce the need of opiods and its side effects (nausea, vomiting, reduced gut mobility and urinary retention) to facilitate fast and safe recovery and enhance rehabilitation [8].
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Yannick NT Van Den Eeden (2018) conducted an RCT in Osteoarthritis and avascular necrosis requiring total hip arthroplasty (n=106). High-volume local infiltration analgesia (LIA) with ropivacaine, epinephrine, and ketorolac vs. 150 mL saline 0.9% (Placebo) was evaluated on Mean opioid (piritramide) consumption 24 hours after surgery (mg) (p=0.02). Intraoperative high-volume local infiltration analgesia significantly reduced mean 24-hour opioid consumption (1.15 mg vs 2.52 mg, p=0.02) compared to placebo in patients undergoing direct anterior total hip arthroplasty.
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