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The scanning mechanism supports cap-dependent initiation in eukaryotes; leaves open roles in non-canonical or disease contexts.
In eukaryotic cells, the translation of the majority ofmessenger RNAs is initiated by a scanning mechanism(Kozak 1989) whereby the 40S ribosomal subunit is recruited to the 5′-terminal end of the capped mRNA as a43S complex, consisting of the 40S ribosome, the ternaryMet-tRNAi/eIF2-GTP complex, and factors eIF1A andeIF3 (Hershey and Merrick 2000). The 43S complex thenscans the mRNA in an ATP-dependent manner until it locates an appropriate start AUG where the 60S subunitjoins to form an 80S ribosome...
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Jan et al. (2001) studied this question.
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