Key result
A female neonate with nemaline myopathy who sustained multiple long bone fractures during an emergency cesarean section achieved good bone union and callus formation with no deformity after 8 weeks of splinting and immobilization.
Why the study?
The authors aimed to describe the presentation of multiple long bone fractures in neonates as an obstetric complication associated with nemaline myopathy.
Case Report (n=1)
Nemaline myopathy can present with neonatal multiple long bone fractures, which can heal well with conservative management like splinting.
Supports splinting for union in neonatal nemaline myopathy fractures; hypothesis-generating for rare genetic fracture management.
Nemaline myopathy is a rare genetic disorder caused by a mutation in genes encoding skeletal muscle proteins resulting in generalized hypotonia. It can be associated with neonatal multiple long bone fractures. We present a female neonate who had bilateral humerus and left femur fractures. Due to fetal distress, her delivery was at 37 weeks gestation by emergency cesarean section. The child was splinted and followed up for 8 weeks. She had a good union of fractured bones, callus formation, and no deformity. Muscle biopsy showed nemaline myopathy. Other biochemical and genetic tests were normal. The aim of this case report was to describe the presentation of multiple long bone fractures in neonates as an obstetric complication. Therefore, identifying the potential risk factors and planning the mode of delivery in future pregnancies, is critical in their management.
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Ghaithi et al. (2022) conducted a case report in Neonatal multiple long bone fractures and nemaline myopathy (n=1). Splinting and immobilization was evaluated on Fracture healing. A female neonate with nemaline myopathy who sustained multiple long bone fractures during an emergency cesarean section achieved good bone union and callus formation with no deformity after 8 weeks of splinting and immobilization.
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