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July 27, 2004Ultrasound in Obstetrics and Gynecology

Prenatal diagnosis of fetal skeletal dysplasias by combining two‐dimensional and three‐dimensional ultrasound and intrauterine three‐dimensional helical computer tomography

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To evaluate the diagnostic accuracy and clinical value of combining three-dimensional ultrasound and intrauterine three-dimensional helical computed tomography with conventional two-dimensional ultrasound for diagnosing fetal skeletal dysplasias.
Prospective single-center study conducted between May and October 2003 involving six pregnant women (N=6) carrying fetuses with suspected skeletal dysplasia.
Patients underwent conventional 2D-US followed by 3D-US and intrauterine 3D-HCT between 27 and 36 weeks' gestation, with imaging findings evaluated against postnatal radiological outcomes.
3D-US and 3D-HCT achieved accurate diagnoses in all cases (100%, 6/6), including three cases of achondroplasia, two of osteogenesis imperfecta type II, and one of chondrodysplasia punctata, whereas 2D-US was accurate in four cases (66.7%, 4/6).
3D-HCT identified 94.3% (33/35) of all skeletal abnormalities and 3D-US identified 77.1% (27/35), both detecting significantly more anomalies than 2D-US at 51.4% (18/35; P < 0.01), with 3D-HCT uniquely enabling full-body fetal visualization.

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Prospective study demonstrates superior diagnostic accuracy combining three-dimensional ultrasound and helical computed tomography in fetal skeletal dysplasia, indicating improved prenatal assessment.

Cite This Study

Ruano et al. (2004) studied this question.

synapsesocial.com/papers/6a97f13ad08ffd74dfc63832 https://doi.org/10.1002/uog.1113

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Prenatal diagnosis of fetal skeletal dysplasias by combining two‐dimensional and three‐dimensional ultrasound and intrauterine three‐dimensional helical computer tomography

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Cite This Study

Prenatal diagnosis of fetal skeletal dysplasias by combining two‐dimensional and three‐dimensional ultrasound and intrauterine three‐dimensional helical computer tomography

Key Points

Discussion

Implication

Cite This Study

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