Key result
Higher circulating plasma omentin levels were significantly associated with a decreased multiplicity of metabolic risk factors (OR 0.017 for having 3-4 risk factors).
Why the study?
Are plasma omentin levels associated with the number of metabolic risk factors in Japanese men?
Cross-Sectional (n=201)
No
Are plasma omentin levels associated with the number of metabolic risk factors in Japanese men?
Lower circulating omentin levels correlate with an increased number of metabolic risk factors, highlighting its potential as a biomarker for metabolic disorders.
Answers are grounded in this paper and cite their sources.
May support omentin as a biomarker for metabolic risk clustering; hypothesis-generating and requires prospective validation before clinical adoption.
BACKGROUND: Omentin is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of omentin with the number of metabolic risk factors. FINDING: The study population comprised 201 Japanese men who underwent annual health checkups. Plasma omentin levels were determined by enzyme-linked immunosorbent assay. We divided the subjects into 4 groups according to omentin levels. A reduction of plasma omentin levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, dyslipidemia, high blood pressure and glucose intolerance. CONCLUSIONS: Circulating omentin levels negatively correlated with the multiplicity of metabolic risk factors, suggesting that omentin acts as a biomarker of metabolic disorders.
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Shibata et al. (2012) conducted a cross-sectional in Metabolic risk factors (n=201). Plasma omentin levels vs. Lower plasma omentin levels was evaluated on Presence of 3-4 metabolic risk factors (OR 0.017, 95% CI -0.013, -0.004, p=<0.001). Higher circulating plasma omentin levels were significantly associated with a decreased multiplicity of metabolic risk factors (OR 0.017 for having 3-4 risk factors).
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