Key result
Higher serum omentin levels were independently associated with a reduced risk of metabolic syndrome (OR 0.639; 95% CI 0.432-0.945) and obesity (OR 0.700; 95% CI 0.563-0.870) among adolescents.
Why the study?
The association of omentin with metabolic syndrome, its components, and obesity in adolescents required investigation.
Are serum omentin levels associated with metabolic syndrome and obesity in adolescents?
Cross-Sectional (n=742)
Are serum omentin levels associated with metabolic syndrome and obesity in adolescents?
Higher serum omentin levels are independently associated with a lower risk of metabolic syndrome and obesity in adolescents.
Answers are grounded in this paper and cite their sources.
Omentin-MetS associations in adolescents are hypothesis-generating; prospective studies needed before any clinical consideration.
Purpose: We investigated the association of omentin with metabolic syndrome (MetS), MetS components, and obesity in adolescents. Methods: A total of 742 middle-school students from Liaoyang City were enrolled in this cross-sectional study using the stratified cluster sampling method. Clinical information and blood samples were collected, and serum omentin levels were measured using enzyme-linked immunosorbent assay. Results: Mean plasma omentin levels were lower in male than in female participants (88.25 (interquartile range 63.02– 133.61) vs 99.46 (interquartile range 69.08– 188.35) ng/L, P = 0.004). The participants were divided into four groups according to the quartile (Q) values of omentin from low to high. With increasing omentin levels from Q1 to Q4, the age of adolescents and the proportion of males gradually increased ( P < 0.05), whereas the body mass index (BMI) ( P < 0.05) and prevalence of MetS ( P > 0.05) tended to decrease. Omentin levels were significantly and negatively correlated with waist circumference and BMI (correlation coefficients of ˗0.099 and ˗0.115, respectively). Regression analysis showed that omentin level was independently associated with the risk of MetS (Odds ratio, OR = 0.639, 95% confidence interval, CI (0.432, 0.945)), which was attributed to the association with central obesity (OR = 0.775, 95% CI (0.605, 0.993)) among MetS components. Increased omentin levels also indicated a reduced risk of obesity (OR = 0.700, 95% CI (0.563, 0.870)). Conclusion: Omentin is an independent predictor of MetS and obesity among adolescents in northeast China.
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Sun et al. (2022) conducted a cross-sectional in Metabolic syndrome and obesity (n=742). Serum omentin levels was evaluated on Risk of metabolic syndrome (MetS) (OR 0.639, 95% CI 0.432, 0.945). Higher serum omentin levels were independently associated with a reduced risk of metabolic syndrome (OR 0.639; 95% CI 0.432-0.945) and obesity (OR 0.700; 95% CI 0.563-0.870) among adolescents.
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