This case report describes a neonatal form of nemaline myopathy complicated by severe microvascular injury and muscle immaturity.
May indicate toxic microvascular injury in neonatal nemaline myopathy; hypothesis-generating and requires validation in larger cohorts.
An infant with a neonatal form of nemaline myopathy showed ultrastructural features of muscle immaturity. Immaturity was characterized by an abnormal presence of myotubes, as well as cells in clusters within a common basement membrane and a great number of satellite cells adhering to very small muscle fibers. In addition, degenerative changes and a severe microvascular lesion were observed. The pathologic findings in the muscle of this patient were those of neonatal nemaline myopathy complicating severe microvascular injury, possibly induced by an unknown toxic agent.
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Fidziańska et al. (1990) studied this question.
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