Synthesis of Model Compound Containing an Indole Spiro-β-lactam Moiety with Vinylchloride in Chartellines

A model compound containing an indole β-lactam moiety bearing vinylchloride in chartellines was synthesized from the Mannich reaction of isatin imine with ketene silyl acetal, β-lactam formation of the resulting β-amino ester, and copper(I)-mediated coupling with (E)-α-chloro-β-iodostyrene.