Groups of mice were inoculated once with graded dilutions of either aluminum phosphate adsorbed or aqueous influenza hemagglutinin vaccine containing A2/Taiwan/1/64 as a primary immunization. Sixty days later each group was divided: one half was given aqueous vaccine and the other, aluminum phosphate adsorbed hemagglutinin. The dose was the same strength as the first. The postbooster antibody response was higher in those groups who had received mineral carrier adsorbed vaccine as the first inoculation (p = .01) indicating that aluminum phosphate adsorbed hemagglutinin is a better conditioner for the secondary response than is aqueous vaccine.
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Hennessy et al. (1971) studied this question.