Key result
This review summarizes the history, etiology, epidemiology, pathogenesis, and clinical features of Long QT syndrome.
This review summarizes the history, etiology, epidemiology, pathogenesis, and clinical features of Long QT syndrome.
May aid genetic-guided LQTS prophylaxis; leaves open prospective validation before routine adoption.
Long QT syndrome (LQTS) is a potentially life-threatening channelopathy, accompanied by a prolonged QT interval on a 12-channel ECG, syncopal conditions and a high risk of sudden cardiac death due to the development of torsade de pointes (TdP) polymorphic ventricular tachycardia. The primary goal in the management of patients with LQTS at the present stage is prevention of undiagnosed forms, its adequate treatment and prophylaxis, facilitated by the rapid development of molecular biology and genetics. The first part of the present review reflects the history of LQTS research and the latest achievements in studying its etiology, epidemiology, pathogenesis and clinical features.
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Kalatsei et al. (2018) conducted a review in Long QT syndrome. This review summarizes the history, etiology, epidemiology, pathogenesis, and clinical features of Long QT syndrome.
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