Total Synthesis of (+)‐Apiosporamide: Assignment of Relative and Absolute Configuration

Antipodal relationship: A convergent synthetic pathway leading to 4-hydroxy-2-pyridinones was involved in the synthesis of apiosporamide (1) and YM-215343 (2). Both have an antipodal relationship to the natural metabolites, whose relative and absolute configurations have been established. Activated β-alanine enolate equivalents derived from β-lactams were the key to the synthesis.