Key result
A clinical nomogram incorporating sex, age, BMI, mean osmotic pressure, SOFA score, and mean albumin predicted in-hospital mortality with an AUC of 0.821, outperforming the SOFA score alone.
Why the study?
Predicting patient mortality provides a clinical reference, and this study aimed to construct a nomogram to improve mortality prediction accuracy.
Does a clinical nomogram combined with SOFA score accurately predict in-hospital mortality in ICU patients?
Observational (n=9,276)
No
Does a clinical nomogram combined with SOFA score accurately predict in-hospital mortality in ICU patients?
Effect estimate: AUC 0.821 (95% CI 0.795-0.846)
Absolute Event Rate: 0.821% vs 0.746%
A clinical nomogram incorporating risk factors and the SOFA score demonstrates good discriminative ability for predicting in-hospital mortality among ICU patients.
Nomogram with SOFA shows good ICU mortality discrimination; leaves open prospective validation before clinical adoption.
Predicting the mortality of patients provides a reference for doctors to judge their physical condition. This study aimed to construct a nomogram to improve the prediction accuracy of patients' mortality. Patients with severe diseases were screened from the Medical Information Mart for Intensive Care (MIMIC) III database; 70% of patients were randomly selected as the training set for the model establishment, while 30% were used as the test set. The least absolute shrinkage and selection operator (LASSO) regression method was used to filter variables and select predictors. A multivariable logistic regression fit was used to determine the association between in-hospital mortality and risk factors and to construct a nomogram. A total of 9276 patients were included. The area under the curve (AUC) for the clinical nomogram based on risk factors selected by LASSO and multivariable logistic regressions were 0.849 (95% confidence interval [CI]: 0.835-0.863) and 0.821 (95% CI: 0.795-0.846) in the training and test sets, respectively. Therefore, this nomogram might help predict the in-hospital mortality of patients admitted to the intensive care unit (ICU).
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Liu et al. (2022) conducted an observational in Intensive care unit admission (n=9,276). Clinical nomogram vs. SOFA score alone was evaluated on In-hospital mortality prediction (AUC in test set) (AUC 0.821, 95% CI 0.795-0.846). A clinical nomogram incorporating sex, age, BMI, mean osmotic pressure, SOFA score, and mean albumin predicted in-hospital mortality with an AUC of 0.821, outperforming the SOFA score alone.
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