Key result
SSRI therapy in postmenopausal women with generalized anxiety disorder was associated with significantly decreased bone mineral density compared to healthy volunteers.
Why the study?
Does SSRI therapy decrease bone mineral density in postmenopausal women with generalized anxiety disorder?
Cross-Sectional (n=100)
No
Does SSRI therapy decrease bone mineral density in postmenopausal women with generalized anxiety disorder?
p-value: p=<0.05
SSRI therapy for at least 12 months in postmenopausal women with generalized anxiety disorder is associated with decreased bone mineral density.
Association with lower BMD supports monitoring bone health in SSRI-treated postmenopausal women with GAD; leaves open causality.
UNLABELLED: Sixty patients diagnosed with generalized anxiety disorder and treated with either paroxetine, sertraline, or citalopram for at least 12 months were enrolled in this study, and the bone mineral density (BMD) of the patients was compared with that of 40 healthy volunteers. Selective serotonin reuptake inhibitor (SSRI) therapy in generalized anxiety disorder was found to be related with decreased BMD values. INTRODUCTION: The objectives of this study were to evaluate the effect of SSRI therapy on BMD in postmenopausal women diagnosed with generalized anxiety disorder (GAD) and to identify the effects of the duration of disease and treatment on risk factors for osteoporosis. METHODS: Sixty patients diagnosed with GAD and treated with paroxetine, sertraline, or citalopram from the SSRI group for at least 12 months were enrolled. Social demographic features, the Hamilton Anxiety Scale (HAS) results, and the Hamilton Depression Scale (HDS) scores of all the patients were assessed. The BMD of the patients was measured by dual-energy X-ray absorptiometry (DXA) at the femoral and lumbar regions. The patients were divided into three groups which are the paroxetine, sertraline, and citalopram groups. The BMD of the patients was compared with that of 40 healthy volunteers. RESULTS: The L2-L4, total lumbar vertebrae, femoral intertrochanteric, total femoral Z-scores, and femoral Ward's region T-scores of the treatment group were lower than the median T- and Z-scores of the control group (p < 0.05). Of the treatment groups, the femoral neck, trochanteric and intertrochanteric T- and Z-scores, total femoral T- and Z-scores, and femoral Ward's T- and Z-scores of the sertraline group were significantly lower than the BMD values measured at the identical regions in the paroxetine and citalopram groups (p < 0.05).There was a significant negative correlation between the duration of treatment and the BMD values. CONCLUSION: SSRI therapy in GAD was found to be related with decreased BMD values. Further randomized controlled studies are warranted to determine whether SSRI use is a risk factor for osteoporosis; such studies should investigate these factors by performing BMD assessments before treatment.
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Ak et al. (2014) conducted a cross-sectional in Generalized anxiety disorder (n=100). Selective serotonin reuptake inhibitors vs. Healthy volunteers was evaluated on Bone mineral density (T-scores and Z-scores) (p=<0.05). SSRI therapy in postmenopausal women with generalized anxiety disorder was associated with significantly decreased bone mineral density compared to healthy volunteers.
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