Healthcare Costs for Treating Relapsing Multiple Sclerosis and the Risk of Progression: A Retrospective Italian Cohort Study from 2001 to 2015

Figures

• 

  Fig 1. Patient disposition flow diagram. Patient disposition flow diagram showing patients included, excluded or lost-to-follow-up within the study cohort. MS: Multiple Sclerosis; RRMS: Relapsing-Remitting Multiple Sclerosis.

• 

  Fig 2. Kaplan-Meier curves for the probability of relapse occurrence, of 1-point EDSS progression, of reaching of EDSS 4.0, of reaching of EDSS 6.0, and of SP conversion, in relation to annual healthcare costs before the specific study endpoint was reached. Kaplan-Meier plots estimating the probability of relapse occurrence (A), of experiencing 1-point EDSS progression (B), of reaching of EDSS 4.0 (C), of reaching of EDSS 6.0 (D), and of SP conversion (E), in relation to the annual healthcare costs before the specific study endpoint was reached. P-values and hazard ratios (HR) are shown from time varying Cox regression models. For graphical purposes, healthcare costs have been categorized on the median value (the red line represents costs lower than the median value, whereas the blue line represents costs higher than the median value). EDSS: Expanded Disability Status Scale; HR: Hazard Ratio.

• 

  Fig 3. Scatter plot for overall annual healthcare costs and relapses. Scatter plot showing the relationship between overall annual healthcare costs and the ARR. P-value and coefficient from Poisson regression analysis are shown; 95% confidence intervals are represented in grey shadow. ARR: Annualised Relapse Rate; Coef: Coefficient.