Describes a fatal case of puerperal cardiomyopathy with granulomatous and eosinophilic myocarditis, potentially linked to sulphamethoxypyridazine hypersensitivity.
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Fatal hypersensitivity myocarditis may occur with sulphamethoxypyridazine in puerperium; single case leaves open causality and incidence.
Summary A fatal case of puerperal cardiomyopathy in a 28‐year‐old woman is described. Congestive cardiac failure with episodes of collapse and hypotension developed about a month after confinement. Acute renal tubular necrosis supervened, necessitating dialysis, and the patient died after a brief illness. Necropsy revealed granulomatous and eosinophilic myocarditis. The aetiology of the lesion was not established but there are grounds for suspecting that it was due to hypersensitivity to sulphamethoxypyridazine.
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Parsons et al. (1971) studied this question.
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