Key result
Non-linear spectral analysis (NLSA) was superior to spectral analysis (SA) in identifying and quantifying the irreversible trapping component for low values of trapping in ex vivo perfused hearts.
Spectral-based quantitative analysis methods, particularly non-linear spectral analysis, are adequate and superior to linear methods for characterizing PET tracer kinetics in ex vivo perfused hearts.
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NLSA may refine low-trapping PET quantification in ex vivo models; leaves open in vivo validation and clinical translation.
Mariotti et al. (2013) studied Isolated perfused rat hearts (n=7). Non-linear spectral analysis (NLSA) vs. Spectral analysis (SA) was evaluated on Accuracy in identifying and quantifying the irreversible trapping component (α0). Non-linear spectral analysis (NLSA) was superior to spectral analysis (SA) in identifying and quantifying the irreversible trapping component for low values of trapping in ex vivo perfused hearts.
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