Population
Three pig cell lines and CHO cells transfected with human DAF, pig DAF, pig CAR, or human CAR
Design
Preclinical
Authors
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CVB uses pig CAR, not DAF, for cell entry; extends cross-species receptor data but leaves open translation to human disease or therapies.
Coxsackie B viruses utilize the pig coxsackievirus/adenovirus receptor (CAR), rather than pig DAF, to infect pig cells.
Spiller et al. (2002) studied this question.
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