October 1, 1998Journal of VirologyOpen Access

The Coxsackievirus-Adenovirus Receptor Protein Can Function as a Cellular Attachment Protein for Adenovirus Serotypes from Subgroups A, C, D, E, and F

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Population

Recombinant fiber knobs, 3H-labeled Ad virions from serotypes representing all six subgroups, and CHO cells…

Comparison

Binding and cross-competition assays using… vs Untransformed CHO cells

Design

Preclinical

Authors

PRPeter W. RoelvinkGenVec ALAlena LizonováGenVec JLJennifer G. M. LeeGenVec

Discussion

Member takes

Implication

CAR usage distinguishes most adenovirus subgroups from B; leaves open vector tropism implications for human gene therapy.

Structured PICO

Population

Recombinant fiber knobs, 3H-labeled Ad virions from serotypes representing all six subgroups (A to F), and CHO cells expressing human CAR

Intervention

Binding and cross-competition assays using soluble recombinant CAR (sCAR) and CHO cells expressing human CAR

Comparator

Untransformed CHO cells

Outcome

Binding of adenovirus serotypes to CARsurrogate

The study identifies that the coxsackievirus-adenovirus receptor (CAR) serves as a cellular attachment protein for multiple adenovirus serotypes across subgroups A, C, D, E, and F.

Cite This Study

Roelvink et al. (1998) studied this question.

synapsesocial.com/papers/6a77a78e137c7dcc81bdf7ec https://doi.org/10.1128/jvi.72.10.7909-7915.1998

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