Key result
Thiopental significantly decreased muscle tone compared to midazolam during the reduction of anterior shoulder dislocation (p=0.014).
Why the study?
Does thiopental improve sedative effectiveness compared to midazolam in patients undergoing reduction of shoulder dislocation?
RCT (n=70)
Double-blind
Block randomization
Yes
Does thiopental improve sedative effectiveness compared to midazolam in patients undergoing reduction of shoulder dislocation?
Thiopental may be a more effective sedative and relaxant agent than midazolam for the reduction of shoulder dislocation.
Offers no definitive guidance on thiopental versus midazolam; leaves open need for randomized trials in shoulder reduction.
BACKGROUND: Various sedative drugs have been proposed to control anxiety and agitation in shoulder dislocation, but none of them has been diagnosed as the best sedative and relaxant agent. The study aimed to compare the sedative effectiveness of thiopental versus midazolam in reduction of shoulder dislocation. METHODS: saturation, patient's pain score and adverse events were all recorded. CONCLUSION: Thiopental might be more effective and relaxant than midazolam for reduction of shoulder dislocation.
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Vahidi et al. (2018) conducted an RCT in Anterior shoulder dislocation (n=70). Thiopental vs. Midazolam 0.1 mg/kg IV (with 2 µg/kg IV fentanyl) was evaluated on Degree of muscle relaxation (muscle tone on 1-5 ordinal scale) (MD 0.37, 95% CI -0.10 to 0.84, p=0.014). Thiopental significantly decreased muscle tone compared to midazolam during the reduction of anterior shoulder dislocation (p=0.014).
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