Key result
Human adenovirus was detected in 5.6% of children with acute gastroenteritis in North India, with HAdV-B3 being the most prevalent serotype.
Cross-Sectional (n=250)
Yes
HAdV-B, particularly serotype B3, is the most prevalent adenovirus strain among North Indian children with acute gastroenteritis.
May inform regional HAdV surveillance in pediatric gastroenteritis; hypothesis-generating for serotype-specific burden.
Introduction: Viral gastroenteritis is an important cause of childhood morbidity and mortality, in developing countries. Human adenovirus (HAdV) poses a major risk in children, elderly people and immunocompromised persons, causes acute diarrhea at irregular intervals as well as in outbreaks. Aim: The study was aimed to investigate the molecular characterization and associated clinical features of HAdV infection in North Indian children affected with acute gastroenteritis (AGI) infection. Materials and Methods: HAdV has been identified by PCR, targeting partial hexon gene from fecal specimen of 250 AGI affected children. Results: A total 14 (5.6%) HAdV positives were confirmed by PCR, among them 8 males (3.2%) and 6 (2.4%) were females. Maximum positivity was 57.14% in the age group of 0-5 years AGI affected children. HAdV-B was the most prevalent followed by C, D, F and A in North Indian children, out of them serotype B3 (28.57%) was prevalent, followed by C2, C5 and F41 (14.29% each); A12, B34, D63 and D28 (7.14% each).
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Tripathi et al. (2016) conducted a cross-sectional in Acute gastroenteritis (n=250). Human adenovirus infection was evaluated on Prevalence of Human Adenovirus (HAdV). Human adenovirus was detected in 5.6% of children with acute gastroenteritis in North India, with HAdV-B3 being the most prevalent serotype.
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