What question did this study set out to answer?

Characterize the bacterial diversity associated with bacterial vaginosis using molecular techniques and assess how community composition influences treatment response.

September 20, 2011PLoS ONEOpen Access

The Complex Vaginal Flora of West African Women with Bacterial Vaginosis

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Authors

SDSylvie DeslandesUniversidade Federal do Paraná GGGeneviève GirouxUniversité de Sherbrooke FSF. SobelaPan African Tsetse and Trypanosomiasis Eradication Campaign

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Implication

Clinical trial reveals improved cure rates among women with greater bacterial vaginosis flora diversity, suggesting symbiotic bacterial interactions influence antibiotic response.

Key Points

Characterize the bacterial diversity associated with bacterial vaginosis using molecular techniques and assess how community composition influences treatment response.
Conducted a secondary analysis of 1555 participants across four West African countries enrolled in a clinical trial evaluating vaginal discharge management, where 843 (54%) had bacterial vaginosis.
Detected nucleic acids of 13 bacterial genera and species potentially linked to bacterial vaginosis using polymerase chain reaction.
Multivariate analysis showed Gardnerella vaginalis, Bifidobacterium, Megasphaera elsdenii, Dialister, Mycoplasma hominis, Leptotrichia, and Prevotella were independently associated with bacterial vaginosis, whereas Lactobacillus and Peptoniphilus absence was associated with the condition.
Excluding Lactobacillus, the other 12 microorganisms were all significantly inter-correlated (p≤0.001), with bacterial prevalence differing by age, sexual activity, and HIV status.
Following treatment with metronidazole or tinidazole regimens, complete symptom resolution by day 14 increased with the number of bacterial genera or species present at baseline.

Cite This Study

Deslandes et al. (2011) studied this question.

synapsesocial.com/papers/6a9511daa9fda6dc960f3b01 https://doi.org/10.1371/journal.pone.0025082

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Implication

Clinical trial reveals improved cure rates among women with greater bacterial vaginosis flora diversity, suggesting symbiotic bacterial interactions influence antibiotic response.

The Complex Vaginal Flora of West African Women with Bacterial Vaginosis

Discussion

Member takes

Implication

Key Points

Cite This Study

The Complex Vaginal Flora of West African Women with Bacterial Vaginosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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