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February 13, 2023Frontiers in SurgeryOpen Access

Maternal and fetal outcomes of pregnant women with bacterial vaginosis

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Authors

BNBeng Kwang NgJCJoo Ngor ChuahFCFook‐Choe Cheah

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Overview

Prospective cohort study shows increased preterm birth and neonatal respiratory complications in pregnant women with bacterial vaginosis, indicating the need for timely screening.

Key Points

  • To assess maternal and fetal clinical outcomes among pregnant women diagnosed with bacterial vaginosis presenting with symptoms of preterm labor, membrane rupture, or abnormal discharge.
  • Conducted a prospective cohort study from December 2014 to December 2015 evaluating 237 women between 22 and 34 weeks of gestation presenting with abnormal vaginal discharge, preterm labor, or preterm prelabor rupture of membranes.
  • Diagnosed bacterial vaginosis using vaginal swab culture and sensitivity, BVBlue testing, and polymerase chain reaction for Gardnerella vaginalis.
  • Bacterial vaginosis was diagnosed in 10.1% (24/237) of participants, with Gardnerella vaginalis detected in 66.7% (16/24) of positive cases.
  • Women with bacterial vaginosis had a significantly higher rate of preterm birth before 34 weeks compared to uninfected women (22.7% vs. 6.2%, p = 0.019), and 55.6% exhibited histologic chorioamnionitis despite no significant differences in clinical chorioamnionitis or endometritis.
  • Neonatal morbidity was elevated in the bacterial vaginosis group, including higher rates of intensive care admission (41.7% vs. 19.0%, p = 0.010), respiratory distress syndrome (33.3% vs. 9.0%, p = 0.002), and intubation (29.2% vs. 7.6%, p = 0.004).

Cite This Study

Ng et al. (2023) studied this question.

synapsesocial.com/papers/6a95124c2bbceb0bf3f576a6https://doi.org/10.3389/fsurg.2023.1084867
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High Atopobium vaginae and Gardnerella vaginalis Vaginal Loads Are Associated With Preterm Birth2014 · 117 citations
  2. 2Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy2009 · 435 citations
  3. 3Gardnerella vaginalisIsolated from Patients with Bacterial Vaginosis and from Patients with Healthy Vaginal Ecosystems2001 · 115 citations
  4. 4A multiplex real-time PCR assay for routine diagnosis of bacterial vaginosis2015 · 76 citations
  5. 5High Global Burden and Costs of Bacterial Vaginosis: A Systematic Review and Meta-Analysis2019 · 507 citations