Key result
High sensitivity C reactive protein (HsCRP) was significantly associated with the development of atrial fibrillation in patients with hyperthyroidism (OR 11.19; 95% CI 1.80-69.53; P=0.003).
Why the study?
Is inflammation associated with the development of atrial fibrillation in patients with hyperthyroidism?
Observational (n=100)
Is inflammation associated with the development of atrial fibrillation in patients with hyperthyroidism?
Odds Ratio: 11.19 (95% CI 1.8–69.53)
p-value: p=0.003
Inflammation (indicated by elevated HsCRP), higher free T4 levels, and increased left atrial diameter are strongly associated with atrial fibrillation in patients with newly diagnosed hyperthyroidism.
Supports inflammation-AF link in hyperthyroidism; hypothesis-generating and should not yet change practice.
OBJECTIVES: The aim of this study was to evaluate the relationship between inflammation and development of atrial fibrillation (AF) in patients with hyperthyroidism. METHODS: A total of 65 patients with newly diagnosed hyperthyroidism, 35 of whom were in sinus rhythm and 30 of whom in AF. Thirty five age- and gender-matched patients in a control group were included in the study. Factors associated with the development of AF were evaluated by multivariate regression analysis. RESULTS: FACTORS ASSOCIATED WITH AF IN MULTIVARIATE ANALYSIS INCLUDED HIGH SENSITIVITY C REACTIVE PROTEIN (HSCRP) [ODDS RATIO (OR): 11.19; 95% confidence interval (95% CI): 1.80-69.53; P = 0.003], free T4 (OR: 8.76; 95% CI: 2.09-36.7; P = 0.003), and left atrial diameter (OR: 1.25; 95% CI: 1.06-1.47; P = 0.008). CONCLUSIONS: The results of the present study suggest that HsCRP, an indicator of inflammation, free T4 and left atrial diameter are associated with the development AF in patients with hyperthyroidism.
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Özaydın et al. (2013) conducted an observational in Hyperthyroidism (n=100). High sensitivity C reactive protein (HsCRP) was evaluated on Development of atrial fibrillation (AF) (OR 11.19, 95% CI 1.80-69.53, p=0.003). High sensitivity C reactive protein (HsCRP) was significantly associated with the development of atrial fibrillation in patients with hyperthyroidism (OR 11.19; 95% CI 1.80-69.53; P=0.003).
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