September 1, 1992Endocrinology

Actions of endothelin-1 on swine ovarian (granulosa) cells.

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Population

Swine ovarian (granulosa) cells in serum-free cultures

Comparison

Endothelin-1 (ET-1) vs Basal conditions, vasopressin, tumor necrosis…

Design

Preclinical

Authors

JFJorge A. FloresInstituto Nacional de Neurología y Neurocirugía SQShahed QuyyumiStaten Island University Hospital DLD.A. LeongUniversity of Alabama at Birmingham

Discussion

Member takes

Implication

Hypothesis-generating for ET-1 modulation of granulosa cells; leaves open in vivo relevance to ovarian function.

Structured PICO

Population

Swine ovarian (granulosa) cells in serum-free cultures

Intervention

Endothelin-1 (ET-1)

Comparator

Basal conditions, vasopressin, tumor necrosis factor-alpha, or inactive phorbol

Outcome

Inositol phosphate accumulation, cytosolic free Ca2+ ion concentrations ([Ca2+]i), and basal and FSH-stimulated progesterone and cAMP accumulationsurrogate

Endothelin-1 activates an intracellular signaling pathway involving inositol phosphates, calcium, and protein kinase-C in mammalian granulosa cells, inhibiting FSH-stimulated progesterone and cAMP accumulation.

Cite This Study

Flores et al. (1992) studied this question.

synapsesocial.com/papers/6a95151aabd4c05a5bf58934 https://doi.org/10.1210/endo.131.3.1324159

View Full Paper

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Actions of endothelin-1 on swine ovarian (granulosa) cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Actions of endothelin-1 on swine ovarian (granulosa) cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider