Exploration on the Mechanism of Xuanmai Ganjie Decoction in the Treatment of Children’s Atopic Cough Based on Network Pharmacology

In order to explore the pharmacodynamic material basis and mechanism of Xuanmai Ganjie Decocyion in the treatment of Children’s atopic cough by means of network pharmacology. Through the Herb database, the main chemical components and targets of Xuanmai Ganjie Decoction were searched, supplemented in the combination with the literature. We searched The targets related to AC diseases were obtained through human gene database (Gencards), online mendelian inheritance in man(OMIM). Then we obtained the common targets of active components of drug and disease targets. The protein-protein interaction network of drug and disease common targets was constructed based on String platform, The PPI network was built through Cytoscape 3.7.2, and the cytohubba analyzed the key targets of Xuanmai Ganjie Decoction in the treatment of AC. GO and KEGG enrichment analysis was carried out using the Metascape website, and bubble charts were drawn using the WeScape online website. Resultly, a total of 82 active ingredients and 86 related targets of Xuanmai Ganjie Decoction and 82 related targets of AC were obtained, Cytohubba finally screened out 10 key edges. The enrichment analysis of KEGG pathway mainly involves calcium signaling pathway, chemokine signaling pathway, Th17 cell differentiation and JAK2/STAT3 signaling pathway. The biological process of GO enrichment analysis mainly involves the activation of protein tyrosine kinase. In conclusion, it may act on the chemokine signaling pathway, Th17 cell activation and tyrosine protein kinase activation through targets such as JAK2, STAT3, VEGFA and other targets to play a therapeutic role in AC.