Research progress of pyrazinamide in the treatment of drug-resistant tuberculosis

Pyrazinamide (pyrazinamide) is a nicotinamide analog. As a unique treatment for tuberculosis, antimicrobial drugs have shortened the treatment time, improved the efficiency of treatment, and reduced the recurrence rate, which is different from other common anti-tuberculosis drugs by inhibiting multiple targets, such as energy production, reverse translation, and survival pantothenate/coenzyme A. Therefore, it is used as an irreplaceable part of the second-line treatment of multidrug-resistant tuberculosis. In recent years, a combination of multiple anti-tuberculosis drugs, such as pyrazinamide and rifampin, has been found to improve the radical cure rate of tuberculosis. This review discusses the recent developments in pyrazinamide.