Key result
In a piglet model of cardiopulmonary bypass, milrinone preserved cardiac output and levosimendan increased it by 14%, compared to a 15% decrease in controls.
Why the study?
Do milrinone and levosimendan improve cardiac output and hemodynamics in a piglet model of infant cardiopulmonary bypass?
Population
18 piglets instrumented with systemic, pulmonary arterial, and coronary sinus catheters, pulmonary and…
Comparison
Milrinone or levosimendan administered at 120… vs Control group
Design
Preclinical
Follow-up
120 mins
Authors
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No immediate change to infant CPB care; leaves open whether inodilators improve outcomes in children.
Do milrinone and levosimendan improve cardiac output and hemodynamics in a piglet model of infant cardiopulmonary bypass?
Milrinone and levosimendan effectively prevent increased afterload and preserve or improve cardiac output in a pediatric model of cardiopulmonary bypass.
Stöcker et al. (2006) studied Reduced cardiac output after pediatric cardiopulmonary bypass (n=18). Milrinone and levosimendan vs. Control was evaluated on Cardiac output. In a piglet model of cardiopulmonary bypass, milrinone preserved cardiac output and levosimendan increased it by 14%, compared to a 15% decrease in controls.
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