Rheumatoid arthritis and coronary atherosclerosis: two cousins engaging in a dangerous liaison
Key result
Patients with active rheumatoid arthritis presenting with acute coronary syndrome had higher 30-day all-cause mortality compared with matched controls (15.7% vs. 10.7%).
Why the study?
Does active rheumatoid arthritis increase short-term mortality in patients presenting with acute coronary syndrome?
Population
Patients with active rheumatoid arthritis presenting with an incident acute coronary syndrome.
Design
Editorial
Follow-up
30 days
Authors
Discussion
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Member takes
Implication
Rheumatoid arthritis and atherosclerosis share inflammatory pathophysiological mechanisms, contributing to more severe acute coronary syndrome presentations and higher short-term mortality in patients with rheumatoid arthritis.
Structured PICO
Does active rheumatoid arthritis increase short-term mortality in patients presenting with acute coronary syndrome?
P
Population
Editorial discussing a large Swedish cohort study on the association between active rheumatoid arthritis and worse short-term outcomes following acute coronary syndrome.
C
Comparator
Matched controls without rheumatoid arthritis
O
Outcome
Short-term all-cause mortality (at 30 days after acute coronary syndrome)hard clinical
Main Result
Absolute Event Rate: 15.7% vs 10.7%
Rheumatoid arthritis and atherosclerosis share inflammatory pathophysiological mechanisms, contributing to more severe acute coronary syndrome presentations and higher short-term mortality in patients with rheumatoid arthritis.
Cite This Study
Klingenberg et al. (2015) conducted an editorial in Rheumatoid arthritis and acute coronary syndrome. Active rheumatoid arthritis vs. Matched controls was evaluated on 30-day all-cause mortality after an ACS. Patients with active rheumatoid arthritis presenting with acute coronary syndrome had higher 30-day all-cause mortality compared with matched controls (15.7% vs. 10.7%).