Why the study?
Does removal of vascular endothelium or blockade of nitric oxide and prostacyclin synthesis impair O2 extraction during progressive ischemia in canine skeletal muscle?
Population
24 anesthetized and paralyzed dogs with pump-perfused vascularly isolated hindlimbs
Comparison
Endothelium removal via deoxycholate injection… vs Control dogs (n=8)
Design
Preclinical
Follow-up
90 minutes
Authors
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Endothelial disruption impairs O2 extraction in canine muscle; leaves open relevance to human ischemia or therapy.
Does removal of vascular endothelium or blockade of nitric oxide and prostacyclin synthesis impair O2 extraction during progressive ischemia in canine skeletal muscle?
The vascular endothelium and its products (nitric oxide and prostacyclin) are necessary for achieving maximal oxygen extraction during progressive ischemia in skeletal muscle.
Curtis et al. (1995) studied this question.
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