Why the study?
Does transendocardial CD34+ cell transplantation improve myocardial retention and clinical parameters compared to intracoronary delivery in patients with nonischemic dilated cardiomyopathy?
Population
40 patients with nonischemic dilated cardiomyopathy
Comparison
Transendocardial CD34 cell transplantation vs Intracoronary CD34 cell transplantation
Design
RCT, randomized, open-label blinded study
Follow-up
6 months
Authors
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Supports transendocardial over intracoronary CD34+ delivery for higher retention; extends route-optimization evidence in nonischemic cardiomyopathy trials.
Does transendocardial CD34+ cell transplantation improve myocardial retention and clinical parameters compared to intracoronary delivery in patients with nonischemic dilated cardiomyopathy?
Transendocardial delivery of CD34+ cells yields superior myocardial retention and greater improvements in LVEF, exercise capacity, and NT-proBNP compared to intracoronary delivery in patients with nonischemic dilated cardiomyopathy.
Vrtovec et al. (2013) studied this question.
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