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Box 5: Methylene blue as an antidote for methaemoglobinaemia c Indicated if methaemoglobin concentrations are above 25-30% (lower concentrations usually associated with minor symptoms or an absence of symptoms) c Dose: 2 mg/kg body weight administered intravenously as a 1% solution over 5-10 minutes. Second dose may be required for severe cases c Mechanism of action: acts as a reducing agent to convert methaemoglobin to haemoglobin Education
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Bradberry et al. (2001) studied this question.
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