July 24, 2002Biochemistry

Multiple Secondary Structure Rearrangements during HIV-1 RNA Dimerization

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Population

HIV-1 RNA transcripts (wild-type and mutant)

Comparison

Mutations designed to block distinct steps of… vs Wild-type RNA

Design

Preclinical

Authors

HHHendrik HuthoffGuy's Hospital BBBen BerkhoutAmsterdam University Medical Centers

Discussion

Member takes

Implication

Supports thermodynamic models of HIV-1 RNA folding; leaves open in vivo relevance and therapeutic translation.

Structured PICO

Population

HIV-1 RNA transcripts (wild-type and mutant)

Intervention

Mutations designed to block distinct steps of the refolding cascade

Comparator

Wild-type RNA

Outcome

RNA folding pathway and free energy changes associated with secondary structure rearrangements

This study describes an ordered RNA folding pathway for HIV-1 RNA dimerization, supported by free energy changes during secondary structure rearrangements.

Cite This Study

Huthoff et al. (2002) studied this question.

synapsesocial.com/papers/6a9524e16a42edee3f2c9d4f https://doi.org/10.1021/bi025993n

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Ask AI

Bookmark

Multiple Secondary Structure Rearrangements during HIV-1 RNA Dimerization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Multiple Secondary Structure Rearrangements during HIV-1 RNA Dimerization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider