Why the study?
It was unknown whether TRPV1 channels regulate the electrophysiological characteristics of embryonic stem cell-derived cardiomyocytes, and what underlying mechanism is involved.
Population
Embryonic stem cell-derived cardiomyocytes
Comparison
Pharmacological or functional modulation of TRPV1 channels vs control
Design
Preclinical in vitro experimental study
Authors
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May inform ESC-CM optimization for drug screening; leaves open in vivo roles in cardiac regeneration.
TRPV1 channels play a crucial role in regulating the spontaneous activity of embryonic stem cell-derived cardiomyocytes by controlling sarcoplasmic reticulum calcium release and stimulating Na+/Ca2+ exchanger activity.
Zhao et al. (2021) studied this question.
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