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alpha-Ketoglutaric semialdehyde has been obtained as a product of hydroxyproline through reactions catalyzed by purified enzymes from Pseudomonas. It has been characterized both by chemical and enzymatic derivatives and by comparison with the chemically synthesized compound. This reactive compound, not previously known as a product of biological reactions, may participate in other metabolic pathways.
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Singh et al. (1964) studied this question.
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