Why the study?
Smoking causes arterial stiffness, an independent predictor of cardiovascular events, but mechanisms and treatment options targeting arterial stiffness in smokers with comorbidity need to be reviewed.
Arterial stiffness is a key surrogate marker of cardiovascular risk in smokers and represents a potential therapeutic target for those with cardiorespiratory comorbidities.
Arterial stiffness may warrant targeting in smokers with comorbidities; leaves open whether interventions improve clinical outcomes.
Cigarette smoking has long been considered a risk factor for cardiovascular disease and a major preventable cause of death and disability in developed and developing countries. It is known that smoking can cause endothelial dysfunction and hemodynamic defects such as arterial stiffness. Among various surrogate markers of cardiovascular risk, arterial stiffness plays a central role and is a strong independent predictor of cardiovascular events, in addition to classical cardiovascular risk factors. This review presents the main mechanisms that explain the development of arterial stiffness during smoking, presents various treatment options for arterial stiffness as a therapeutic target for smokers with cardiorespiratory comorbidity.
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Gordeev et al. (2023) studied this question.
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