Chronic Systemic Inflammation Leading Eventually to Myocardial Infarction, Stroke, COPD, Renal Failure and Cancer is Induced by Multiple Risk Factors

Chronic systemic inflammation is implicated in the pathogenesis and progression of various inflammatory diseases including cardiovascular disease, stroke, lung diseases, renal failure and cancer. Multiple risk factors, in addition to hypercholesterolemia, have been reported in the recent literatures which are responsible for the generation of chronic inflammation in various organs. There are five major risk factors that can be identified with relative specific markers including abdominal fat, dyslipidemia, bacterial and viral infection, hyperglycemia and hyperhomocysteinemia. Many minor risk factors such as pollutant, stress, diet and drugs etc. have also been reported. Though not highly publicized these minor risk factors are also playing important role in their impact of chronic inflammation. These minor risk factors are not identified with specific markers; however, multiple inflammation markers such as urinary microalbumin, homocysteine, uric acid and 3-nitrotyrosine are useful for detecting their presence and monitoring the success of treatment.